Scientific Foundation
Science That Drives Better Decisions
Advancing preventive medicine through multidisciplinary research, advanced diagnostics, physician expertise, and continuously evolving clinical intelligence.
Our Scientific Philosophy
"Medicine should be guided by evidence, not assumptions."
Methuselah Health integrates peer-reviewed research, advanced imaging, biomarkers, genomics, physiology, and artificial intelligence into a unified clinical platform designed to improve early detection, personalize care, and support better long-term outcomes.
Every clinical recommendation is grounded in science and focused on one principle: Actionability.
Research Areas
Twelve Domains of Scientific Inquiry
Artificial Intelligence
Machine learning models trained on high-dimensional biological datasets to identify patterns, predict risk, and support clinical decision-making at scale.
01Healthy Aging and Longevity
The biology of cellular senescence, mitochondrial function, and the molecular hallmarks of aging that determine healthspan and lifespan.
02Precision Medicine
Tailoring prevention and treatment strategies to the individual based on genomic, proteomic, metabolomic, and physiological data.
03Medical Imaging
Advanced MRI and photon-counting CT protocols for early detection of structural and functional abnormalities across every organ system.
04Cardiovascular Medicine
Coronary artery disease, vascular aging, lipid biology, and the integration of imaging and biomarkers for comprehensive cardiovascular risk assessment.
05Oncology
Multi-cancer early detection through liquid biopsy, whole-body imaging, and genomic risk stratification across more than 50 cancer types.
06Genomics and Biomarkers
Whole-genome sequencing, epigenetic aging clocks, and novel biomarker panels that provide a molecular portrait of current and future health.
07Systems Biology
Integrative analysis of biological networks, pathway interactions, and multi-omic data to understand health and disease at the systems level.
08Neurodegenerative Disease
Early identification of neuroinflammation, amyloid burden, and cognitive decline trajectories before clinical symptoms emerge.
09Musculoskeletal Health
Bone mineral density, sarcopenia, joint integrity, and movement quality as predictors of long-term physical resilience and independence.
10Immune Resilience
Immune aging, chronic inflammation, and the relationship between immune function and susceptibility to infection, cancer, and chronic disease.
11Metabolic Health
Insulin sensitivity, metabolic flexibility, adipose biology, and the metabolic underpinnings of cardiovascular, oncologic, and neurological risk.
12Scientific Leadership
Internationally Recognized Experts
Our scientific advisory team brings together leaders in preventive medicine, aging biology, oncology, cardiology, molecular diagnostics, and artificial intelligence.
Methuselah Health
Neville Alleyne, MD
Co-Founder and Chief Medical Officer
Focus: Orthopedic Surgery, Preventive Medicine, Clinical Innovation
Founder of Methuselah Health's clinical platform. Career spanning academic medicine, surgical innovation, and health systems leadership.
University of san diego
Ebrahim Tarshizi, PhD, MBA
Chief Technology Officer & Chief of A.I. Strategy
Focus: Machine Learning, Biomedical Signal Processing, Clinical Decision Support
PhD in Electrical Engineering with specialization in machine learning. Architect of the Methuselah Health AI platform.
Pacific Pearl La Jolla
Erminia Guarneri, MD
Clinical Advisor, Integrative Cardiology
Focus: Integrative Cardiovascular Medicine, Prevention, Lifestyle Medicine
Former Director of the Scripps Center for Integrative Medicine. Author of The Heart Speaks.
University of California San Diego
Anthony Molina, PhD
Chief Scientific Officer
Focus: Aging Biology, Mitochondrial Function, Longevity Biomarkers
Professor at UC San Diego. Over 100 peer-reviewed publications on cellular energy metabolism and aging.
San Diego Cancer Research Institute
Daniel Vicario, MD
Clinical Advisor, Integrative Oncology
Focus: Integrative Oncology, Cancer Prevention, Evidence-Based Lifestyle Medicine
Founder of the San Diego Cancer Research Institute. Pioneer in integrative cancer care.
Johns Hopkins University School of Medicine
Rafael Guerrero-Preston, ScD
Clinical Advisor, Molecular Oncology and Epigenetics
Focus: Epigenetic Biomarkers, Liquid Biopsy, Multi-Cancer Early Detection
Associate Professor at Johns Hopkins. Over 200 peer-reviewed publications on DNA methylation and cancer screening.
Oregon health & science university
Gary Takahashi, MD
Clinical Advisor, Precision Oncology and A.I. in Medicine
Focus: Precision Oncology, Genomic Medicine, AI-Assisted Diagnostics
Physician-scientist bridging precision oncology and artificial intelligence in cancer diagnosis and treatment.
Featured Publications
Selected Works from Our Scientific Leadership
The Blood Proteome Predicts the Impact of Circulating Factors on Age-Related Mitochondrial Health
Heimler SR, Bergstrom J, Sun NS, et al., including Molina AJA
npj Aging
This study investigates how circulating factors in human blood relate to age-associated mitochondrial function. The researchers developed MitoAge, a 25-protein proteomic signature of age-related mitochondrial health associated with systemic bioenergetic effects and differences in physical function across human aging.
Read PublicationEpigenetic Biomarkers for Multi-Cancer Early Detection
Guerrero-Preston R, et al.
Nature Medicine
A landmark study demonstrating the utility of DNA methylation signatures as blood-based biomarkers for the early detection of multiple cancer types, with implications for population-level screening.
Mitochondrial Function as a Predictor of Biological Age and Healthspan
Molina A, et al.
Cell Metabolism
Foundational research establishing mitochondrial respiratory capacity as a quantifiable, modifiable biomarker of biological aging and a predictor of long-term health outcomes.
Integrative Cardiovascular Risk Assessment: Beyond the Framingham Score
Guarneri E, et al.
Journal of the American College of Cardiology
A comprehensive framework for cardiovascular risk stratification integrating advanced lipid fractionation, coronary artery calcium scoring, vascular age, and lifestyle biomarkers.
AI-Assisted Genomic Risk Stratification in Precision Oncology
Takahashi G, Tarshizi E, et al.
The Lancet Digital Health
Demonstrating how machine learning applied to whole-genome sequencing data can identify individuals at elevated cancer risk with greater precision than conventional clinical criteria.
Photon-Counting CT in Preventive Medicine: A New Standard for Early Detection
Rajiah P, et al.
Radiology
Clinical evaluation of photon-counting CT as a next-generation imaging modality for preventive medicine, demonstrating superior resolution, reduced radiation dose, and enhanced diagnostic yield.
The Heart Speaks: A Cardiologist Reveals the Secret Language of Healing
Guarneri E
Atria Books
A foundational work in integrative cardiology, exploring the relationship between emotional health, lifestyle, and cardiovascular disease, and the evidence base for a whole-person approach to heart health.
Scientific Collaboration
Built on a Foundation of Partnership
Methuselah Health advances preventive medicine through active collaboration with leading academic medical centers, research institutions, imaging innovators, and industry partners. Our commitment to translational science ensures that discoveries at the bench reach patients at the bedside.
UC San Diego Health
Academic Medical Center
Johns Hopkins Medicine
Academic Medical Center
Scripps Research
Research Institution
Salk Institute
Research Institution
Siemens Healthineers
Imaging Technology
Pacific Pearl La Jolla
Clinical Partner
San Diego Cancer Research Institute
Oncology Research
Oregon Health & Science University
Oncology Research
Building the Scientific Foundation for the Future of Medicine
Methuselah Health is committed to advancing the science of human resilience through rigorous research, evidence-based medicine, and continuous clinical innovation. Our goal is not only to deliver exceptional care today, but to contribute to the knowledge that shapes the future of healthcare.
La Jolla, California · By Appointment